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Archive for July, 2008

The 2008 International Conference on Alzheimer’s Disease (ICAD) is under way in Chicago. Organized by the Alzheimer’s Association, the event has brought together over 5,000 researchers from around the world to report on current advances in Alzheimer’s research, diagnosis, treatment, and prevention.

 

The presentations on 27 July 2008 included reports on the latest MRI Technologies. In one study at the Roberts Research Institute and University of Western Ontario in Canada, Scientists customized a clinical strength MRI Scanner to detect amyloid plaques in live rabbits showing Alzheimer’s disease pathology. This is significant because in the past, only high-powered MRIs and PET Scanners with Chemical Markers have been able to do this. Conventional MRI Scanners like the one used in the present study are more affordable and available; they also do not expose the subject to radiation like some other methods.

 

In addition to this study, two other ICAD presentations focused on improvements in MRI Technology.

 

This is exciting because better imaging procedures could mean earlier diagnosis of Alzheimer’s and other kinds of dementia, perhaps even before symptoms appear.

 

(Source:  http://alzheimers.about.com/b/a/000105.htm?nl=1)

 

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If you’ve ever experienced senior moments — a nonmedical term for mental glitches — you’re not alone.

 

A few years ago, I was buying groceries and had just swiped my debit card. The machine asked me for my PIN, which I had entered hundreds of times before, and I froze. I couldn’t remember it for the life of me. As the cashier peered at me as if I was a possible identify thief, I quickly cancelled the transaction and switched to a credit card that required no PIN.

 

My grandmother died of Alzheimer’s disease. So did her mother. My father is 70 and shows no signs of the disease, but his mother and grandmother didn’t develop it until their late 80s. We don’t know yet whether the disease will strike three or more generations in a row.

 

Even though I was in my mid-30s when I blanked on my debit PIN, I couldn’t help but wonder if there was something really wrong with me. I guess I was too young to call what happened a senior moment, but in reality, that’s all it was.

 

I was sleep-deprived and stressed that day — two things that can bring on those dreaded senior moments. A few weeks later, I returned to the store, but this time I was calm and rested. I remembered my PIN without a hitch.

 

Over time, the brain often experiences some normal age-related memory loss. This happens for many reasons, such as decreases in neurotransmitters and brain size, which can make it harder to pay attention and process information. People with normal age-related memory loss, though, are usually able to compensate for these changes by using lists and other memory aids. In other words, the senior moments don’t generally impair daily functioning.

 

A common type of senior moment does have a scientific name: literal paraphasia. This is when we mix up similar words, such as “here” and “hear.” Temporarily forgetting names, phone numbers or why you went upstairs (“What was I going to get?”) are also common senior moments.

 

When senior moments make it hard to manage daily affairs, they may be early warning signs of Alzheimer’s disease or another dementia. If you think your senior moments go beyond the realm of minor annoyances and occasional slips, be sure to see a doctor so your symptoms can be evaluated. There could be many causes for your symptoms, but the only way to find out what’s happening is to have a thorough diagnostic workup.

 

What’s troubling is that it’s hard to know whether senior moments will never progress beyond what’s normal or whether the senior moments are the beginning of something worse. There’s also the possibility that those senior moments are signs of mild cognitive impairment (MCI), a middle ground between normal age-related memory loss and dementia. That’s why it’s important to make note of senior moments over time and also ask others to tell you if they’ve noticed that the moments are becoming more frequent.

 

Our fast-paced society probably increases the chances of having senior moments. Multitasking makes it harder to retain facts, because we’re not giving any one piece of information our undivided attention. Also, the fatigue and stress that many of us experience because we’re overworked, reduce our ability to concentrate and pay attention to details.

 

Here are some tips to reduce the incidence of senior moments:

 

·       Do one thing at a time.

·       Notice how things look, smell, taste and feel, as well as what’s happening, in order to remember something in multiple ways.

·       Replay memories in your mind to reinforce them.

·       Get enough sleep.

·       Learn stress management techniques.

·       Reduce mental clutter by using calendars, lists and gadgets such as personal digital assistants (PDAs)

 

Senior moments can be scary, but most of the time they’re just a result of the brain’s normal aging process. Unless they’re interfering with your ability to manage day-to-day activities, a few lifestyle changes should help you turn your senior moments into just occasional annoyances.

 

(Source:  http://alzheimers.about.com/od/symptomsofalzheimers/a/seniormoments.htm?nl=1)

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OUR CHARACTER IS SHOWN BY …

 

The jokes we CHOOSE to share…and not to share.

The derogatory terms we CHOOSE to use…and refuse to use.

The promises we CHOOSE to break…and the ones we keep.

The rumours we CHOOSE to spread…and those we ignore.

The resources we CHOOSE to waste…and those we use wisely.

The lies we CHOOSE to tell…and not to tell.

The responsibilities we CHOOSE to accept…and those we shirk.

The courtesies we CHOOSE to extend…and fail to extend.

The efforts we CHOOSE to put forth…and not put forth.

The quality we CHOOSE to provide…and the corners we cut.

The information we CHOOSE to share…and that which we hoard.

The listening we CHOOSE to do and not do.

The respect we CHOOSE to give…and fail to give.

The helpful hands we CHOOSE to extend…and those we keep in our pockets.

(source: www.walkthetalk.com) 

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Scientists have found further evidence that taking commonly used cholesterol- lowering statins may protect against dementia and memory loss.

(Source:  http://news.bbc.co.uk/2/hi/health/7524816.stm)

The study, published in Neurology, found that statins – normally taken to reduce heart disease risk – may cut the risk of dementia by half.

The five-year project examined 1,674 Mexican Americans aged 60 and over at heightened risk of dementia.

The Alzheimer’s Research Trust said the research is “encouraging”.

A quarter of the patients took a statin, and in total 130 went on to develop dementia.

the researchers had taken account of other risk factors, including education, smoking, and diabetes, they calculated that those who took statins had an approximately 50% lower risk of developing dementia.

The study comes hot on the heels of separate research which suggests that drugs to reduce blood pressure can also cut the risk of dementia.

It is estimated that 4 million people in England and Wales alone currently take statins.

Lead researcher Professor Mary Haan, of the University of Michigan, said: “The bottom line is that if a person takes statins over a course of about five to seven years, it reduces the risk of dementia by half, and that’s a really big change.”

Statins help to reduce the risk of heart disease by lowering levels of cholesterol which clog up the blood vessels.

It is thought that a poor supply of blood to the brain may be one factor which promotes the development of dementia.

Therefore, if statins help keep the blood vessels healthy, and blood flowing freely to the brain, they may help protect against the disease.

However, it is still not clear exactly how statins work on the biochemical pathways involved in dementia.

Professor Haan said one possibility is that statins may help to reduce levels of the hormone insulin, which have also been implicated in the development of dementia.

‘Encouraging’ results

Rebecca Wood, of the Alzheimer’s Research Trust, described the research as “encouraging”.

However, she said: “People should not take statins unless medically advised to do as, as side-effects can be unpleasant.

“We need much more research into this possible prevention for dementia.”

Dr Clive Ballard, of the Alzheimer’s Society, said statins were increasingly being touted as a potential cure for dementia.

He said: “The jury is still out on how effective they are, but this study adds to growing evidence that they may have some benefits.

“All drugs have some side-effects so it is important to seek professional advice about medication.”

It is estimated that 700,000 people in the UK live with Alzheimers’. The number is expected to double within a generation as the average age of the population rises.

 

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Being single when you reach middle age could mean more than having the house to yourself – it could increase your risk of dementia.

 

Swedish research, presented at a US conference, found that marriage or having a partner halved the risk of developing dementia.

 

Scientists believe social interaction between couples may ward off illness.

 

The Alzheimer’s Research Trust said the results were worrying, given the high divorce rates in the UK.

 

“This study points to the beneficial effects of a married life.”

 

Rebecca Wood, from the Alzheimer’s Research Trust, said that more research along these lines was urgently needed.

 

“These findings are particularly worrying for the UK – a society with a high divorce rate, marriage at an all-time low, and ageing population.

 

“This is the first study of its kind to examine the link between midlife marital status and dementia, adding to previous research suggesting that social interaction reduces dementia risk.”

 

However, Susanne Sorenson, from the Alzheimer’s Society, had some words of cheer for partnerless people.

 

She said: “Singletons shouldn’t worry – there are many other ways to reduce your risk of dementia that don’t involve popping the question.”

 

“The best evidence is around eating a Mediterranean diet, exercising regularly and not smoking.”

She also said that the findings were consistent with other research showing social interaction could be beneficial.

 

She added: “Whether it’s reaching for the vacuum cleaner or going for long romantic walks, lifestyle factors associated with being married may also help.”

 

(Source:  http://news.bbc.co.uk/2/hi/health/7530867.stm)

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UK scientists have developed a drug which may halt the progression of Alzheimer’s disease

 

Trials of the drug, known as Rember, in 321 patients showed an 81% difference in rate of mental decline compared with those not taking the treatment.

 

The Aberdeen University Researchers said the drug targeted the build-up of a specific protein in the brain.

 

Alzheimer’s Experts were optimistic about the results, but said larger trials were now needed.

 

Presenting the results at the International Conference on Alzheimer’s Disease, Professor Claude Wischik said the drug may be on the market by 2012.

 

Patients with mild to moderate Alzheimer’s disease were given either 30, 60 or 100mg of the drug or a placebo.

 

The 60mg dose produced the most pronounced effect – over 50 weeks there was a seven-point difference on a scale used to measure severity of dementia.

 

At 19 months there was no significant decline in mental function in patients taking the drug, the Researchers said.

 

Imaging data also suggests the drug may be having its biggest effect in the parts of the brain responsible for memory.

 

The link between clumps or “tangles” of protein inside nerve cells in the brain and Alzheimer’s disease was first made over 100 years ago.

 

Later shown to be made up of a protein called Tau, the tangles build up inside cells involved in memory, destroying them in the process.

 

Rember, or methylthioninium chloride, is the first treatment specifically designed to target the Tau tangles.

 

Other treatments for Alzheimer’s tend to focus on combating a waste protein in the brain, beta-amyloid, which is known to form hard plaques. The latest work suggests targeting Tau may produce better results.

 

Methylthioninium chloride is more commonly used as a blue dye in laboratory experiments.

 

Professor Wischik discovered it by accident 20 years ago, when a drop in a test tube led to the disappearance of the Tau protein he had been working on.

 

“We have demonstrated for the first time that it may be possible to arrest the progression of this disease by targeting the tangles which are highly correlated with the disease,” he said.

 

“We did an analysis of the effect size at 24 weeks and at 50 weeks compared to the average effect size of the current treatments and it was about two and a half times better,” he added.

 

Larger trials of the drug are planned to start in 2009, and researchers are also investigating whether the drug has a role in prevention of the disease in the first place.

 

Professor Clive Ballard, head of research at the Alzheimer’s Society, said: “This is a major new development in the fight against dementia.”

 

“It is the first realistic evidence that a new drug can improve cognition in people with Alzheimer’s by targeting the protein tangles that cause brain cell death.”

 

“This first modestly sized trial in humans is potentially exciting.”

 

“It suggests the drug could be over twice as effective as any treatment that is currently available.”

 

Rebecca Wood, Chief Executive of the Alzheimer’s Research Trust, said: “In this exploratory trial, rember reduced the decline in blood flow to parts of the brain that are important for memory.”

 

“This bodes well but we need more human trials to assess the treatment’s possible side effects.”

 

She added the fact the trial was funded by a pharmaceutical company highlighted the lack of funding for Alzheimer’s research in the UK.

 

(Source:  http://newsvote.bbc.co.uk/mpapps/pagetools/print/news.bbc.co.uk/2/hi/health/7525115.stm) 

 

 

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It is great to be well aware of what you can do.

And it’s even better to also acknowledge & accept of what you can’t do.

By Ralph Marston

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Ovarian Cancer is often referred to as the silent killer due to the advanced stage at which most cases are discovered. In the last 30 years, however, medical advancements have allowed us to wage a better fight against the disease, thereby increasing survival rates.

According to Julian Schink, MD, Chief of Gynecologic Oncology at Chicago’s North-Western Memorial Hospital, “Women diagnosed with ovarian cancer today live an average of five times longer than women affected by the disease 30 years ago due to significant advances in how we detect and treat ovarian cancer, and increased awareness of warning signs.”

Warning Signs

Diagnosing ovarian cancer is difficult because there is no reliable screening test. In addition, there were no officially recognized symptoms associated with ovarian cancer until 2007, when the Gynecologic Cancer Foundation, Society of Gynecologic Oncologists, and American Cancer Society issued a statement formally noting the following:

• Bloating

• Pelvic or abdominal pain

• Difficulty eating or feeling full quickly

• Urinary symptoms (urgency or frequency)

Doctors stress that the frequency and number of symptoms are key and that women who experience a combination of these symptoms almost daily for two to three weeks should see their doctor. “Patients should listen to their bodies, be assertive and tell their doctor if a change occurs. It’s important to investigate symptoms thoroughly in order to catch ovarian cancer early,” says Schink.

Reducing Your Risk

One in 55 women will develop ovarian cancer in her lifetime and the risk increases for women who are genetically predisposed. However, Schink notes there are steps you can take to lower your risk:

• Oral contraceptives – women who use birth control pills for at least five years are three times less likely to develop ovarian cancer.

• Tubal ligation-permanent forms of birth control such as tubal ligation reduce the risk of ovarian cancer by 50 percent.

• Removal of ovaries-women with an extensive family history of breast or ovarian cancer, or who carry altered versions of the BRCA genes, may opt for a prophylactic oophorectomy to remove both ovaries, lowering the risk of ovarian cancer by up to 80 percent.

Treatment

While difficult to detect, specialized centres such as the North-Western Ovarian Cancer Early Detection and Prevention Program, a collaborative effort between the hospital and the Robert H. Lurie Comprehensive Cancer Centre, have strategies for monitoring women at risk.
Patients are monitored with ultrasound and blood tests every six months. “The goal of the program is to catch cancer that may develop early, so patients can receive treatment before it reaches an advanced stage,” says Schink. “Studies show that patients who go to a centre of excellence committed to treating ovarian cancer have better outcomes and a greater chance that their cancer will be successfully removed.”

Treatment for ovarian cancer includes surgery to remove the ovaries, uterus and tissues that ovarian cancer often spreads to, the appendix and, in some cases, lymph nodes in the pelvic region. Doctors at North-Western Memorial also use a form of chemotherapy called intraperitoneal chemotherapy, which is injected directly into the abdominal cavity and has been linked to a 15-month improvement in survival.

When asked about the future of ovarian cancer, Schink states he is encouraged by the progress that has been made and that with new drugs, treatments and surgical strategies on the horizon, he is optimistic. “The best scenario would be to prevent this cancer entirely. Until that day comes, we will continue to aggressively seek the best treatment and provide the highest level of care possible to our patients.”

Women diagnosed with ovarian cancer today live an average of five times longer than women affected by the disease 30 years ago.

(Source:  http://www.HealthNewsDigest.com)

 

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Critics of conventional cancer therapy identify the three main treatment modalities thus: slashing (surgical removal of affected tissue), burning (radiation), and poisoning (chemotherapy). While these descriptions might be extreme, they do point out that traditional methods damage a goodly number of healthy cells, along with the cancerous ones. The holy grail of cancer therapy is to selectively attack the tumour cells, and not affect surrounding healthy tissue.Recent research coming out of the University of Texas, presented in a paper entitled “Thermal ablation of tumour cells with antibody-functionalized single-walled carbon nanotubes,” and published in Proceedings of the National Academy of Sciences, suggests that we could be closer to that goal.

A carbon nanotube is a long cylindrical arrangement of carbon atoms, that can be thought of as a sheet of graphite rolled into a cylinder. Perhaps the most studied tubes are the single-walled carbon nanotubes (SWNT). An SWNT can be likened to a nano-sized piece of chicken wire, whereby each “cell” is formed of a hexagonal ring of carbon atoms. One of the many interesting properties of SWNTs is that they emit heat when exposed to near-infrared light.

The most common application of near-infrared is to enable TV remote controls to do their thing. Near-infrared can also penetrate human tissue to a depth of about 1½ inches (3.8 cm).

In this study, cultures of lymphoma cells were utilized. Nanotubes were coated with monoclonal antibodies, that targeted specific sites on the cells. A monoclonal antibody is the real-life embodiment of the magic bullet proposed by Nobel prize winner Paul Ehrlich in the early 1900s. The idea is that should it be possible to create some compound which selectively targeted a certain pathogen, then a toxin for that organism could be delivered—along with the agent of selectivity. As such, this “magic bullet” would kill only the targeted organism.

As it happened in this experiment, the antibody-coated nanotubes did attach to the surface of the lymphoma cells. Upon exposure to the near-infrared light, the tubes heated up and killed the cells. In a control group with nanotubes coated with a different antibody, binding did not occur, and the tumour cells were left unharmed.

Listen to Dr. Ellen Vitetta, Director of the Cancer Immunobiology Centre at UT South-Western and Senior Author of the study:

 

 

“Using near-infrared light for the induction of hyperthermia is particularly attractive because living tissues do not strongly absorb radiation in this range. Once the carbon nanotubes have bound to the tumour cells, an external source of near-infrared light can be used to safely penetrate normal tissues and kill the tumour cells.Demonstrating this specific killing was the objective of this study. We have worked with targeted therapies for many years, and even when this degree of specificity can be demonstrated in a laboratory dish, there are many hurdles to translating these new therapies into clinical studies. We’re just beginning to test this in mice, and although there is no guarantee it will work, we are optimistic.”

 

Of course, one problem that needs to be addressed is the matter of how nanomaterial introduced in vivo could harm the recipient. In other words, what are the side effects of nanotherapy, and how can they be minimized or even eliminated?

Dr. Rockford Draper, another of the lead scientists on the project answers that, “There are rational approaches to detecting and minimizing the potential for nonspecific toxicity of the nanoparticles developed in our studies.”

That sounds promising, but also indicates that much work still remains. The good news is that nanotubes also show promise against a variety of pathogens such as E. coli and B. anthracis. In this era of emerging antibiotic resistant infections, consider it excellent timing.

How long it will take before nanotherapy is actually practical is anybody’s guess. Still, the spirit of Paul Ehrlich must be smiling.

 

 (Source:  http://www.healthnewsdigest.com/news/Cancer_Issues_660/Killing_Cancer_Cells_-_Selectively_-_With_Carbon_Nanotubes.shtml)

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Antioxidants and Omega-3 Fats: Functional Foods to Boost Health

Looking for your meal ticket to health?

You might be wise to go for some omega-3 fatty acids served up with a side of antioxidants. The good news is, it can be as tasty as it is healthy — think grilled salmon and vegetables, drizzled with olive oil and accompanied by a nice glass of red wine.

“People who eat a plant-based diet are the healthiest people on the planet,” says Katherine Tallmadge, MA, RA, LD, an American Dietetic Association Spokeswoman. “Eat at least five cups of fruits and vegetables every day.  Use olive oil instead of butter. Eat plenty of seafood. These are nutrition recommendations that won’t change.”

What is changing is our understanding of how nutrients like omega-3 fatty acids and antioxidants are responsible for the health-promoting properties of functional foods — and what you can do to maximize their effectiveness.

Antioxidants: Vitamins, Flavonoids, and Minerals

Plant foods like fruits and vegetables, whole grains, nuts and seeds are your best bet to obtain disease-fighting antioxidants such as vitamins A, C and E, the mineral selenium, and flavonoids.

The protective benefits of antioxidants seem to stem from their ability to protect your cells from dangerous free radicals, which you are exposed to as the result of natural processes and pollutants in the environment.

When it comes to cancer-fighting properties of the nutrients in a balanced diet, the whole may be more than the sum of its parts. Many scientists now believe that food synergy, or the way nutrients in the different foods you eat interact with one another, may be responsible for the health benefits of a diet rich in fruits and vegetables.

“An important result of research in recent years is less emphasis on any single nutrient, or even any group of a few nutrients, in preventing cancer, with more support for the way that a balanced, plant-based diet provides a bounty of nutrients and compounds that seem to work together to protect us against cancer,” says Karen Collins, MS, RD, CDN, and Nutrition Advisor to the American Institute for Cancer Research.

“Research shows that much of the antioxidant power of a healthy plant-based diet comes not from the traditional vitamins we focus on, but from a wide range of phytochemicals … these compounds seem to work best together, not on their own.”

The benefits you get from eating a diet rich in functional foods loaded with antioxidants go far beyond fighting cancer.

Tallmadge says that people who eat foods rich in antioxidants have many health advantages, including:

· less cancer

· lower inflammation levels

· lower heart disease risk

· less Alzheimer’s and dementia

For the most protection, you should try to eat a wide variety of colorful fruits and vegetables, including garlic and onion, tomatoes, watermelon, leafy greens, broccoli, cauliflower, blueberries, carrots, and bell peppers.

Beverages like tea, coffee, and red wine also contain antioxidants that may offer protection against many diseases, including diabetes, Alzheimer’s, and heart disease.

Omega-3 Fats: Fish Oil for Heart Health

Omega-3 fatty acids are some of the promising functional foods when it comes to your heart health.  A landmark 2006 study of the effects of fish on human health demonstrated that a modest intake of fish reduces the risk of dying from a heart attack by a whopping 36%.

“There is certainly enough evidence now to indicate that eating fish once or twice per week, choosing from a variety of fish, confers a benefit as strong or stronger than any other food for cardiovascular health,” says the study’s Co-Author Dariush Mozaffarian, Co-Director of the Program in Cardiovascular Epidemiology at Harvard Medical School and the Harvard School of Public Health.

The heart-health benefits seem to be greatest with the consumption of two particular omega-3 fatty acids that are found mainly in oily fish — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).  Choose oily, cold-water fish species like salmon, trout, and herring to get the most omega-3s.

What about the mercury in fish?  For most people, it’s more dangerous to avoid eating omega-3 fats than to consume the amount of mercury in most commonly eaten fish species.  The EPA and FDA suggests a limit of 12 ounces (2 average meals) of fish a week for special populations, including women who are or may become pregnant, nursing mothers, and young children. Those groups should avoid fish highest in mercury, such as shark, swordfish, and tilefish.

Fish isn’t the only source of health-boosting omega-3s. You can also find the healthy fats in walnuts, canola oil, and flaxseed.  The omega-3s from plant-based sources, which contain alpha linolenic acid (ALA), may also have cardiovascular benefits, but the evidence is not as strong.

Regardless, all functional foods containing omega-3 fatty acids are thought to boost your health in a variety of ways by lessening inflammation levels in your body.  In the last few years, consuming diets rich in omega-3 fats have been touted for reducing the risk of Type-1 diabetes and, they may even improve your mood.

Functional Foods Trump Supplements

When it comes to choosing whole foods or supplements, most experts agree that it’s best to eat your functional foods, rather than taking a pill.

“Even for something considered as protective as antioxidants, there can be too much of a good thing,” Collins tells WebMD. The 2007 report of the American Institute for Cancer Research on diet and cancer prevention recommends against using supplements for cancer protection at this time.  In fact, some recent studies have demonstrated that beta-carotene, vitamin E, and vitamin A supplements can actually raise your chance of death.

But that doesn’t mean that you should shun all supplements. Certain populations may need supplements of vitamin B-12, folic acid, calcium, or vitamin D:

· People over age 50

· Vegetarians

· Pregnant women

· Children

· Those who rarely get sunshine

You should talk to your Doctor or a Registered Dietitian about your individual needs.

When it comes to heart health, though, there is convincing evidence that fish oil supplements and fish seem to have roughly the same benefits.

“Fish does have other benefits though, like selenium and vitamin D,” Mozaffarian tells WebMD. “If I were choosing, I would choose fish over fish oil pills.”

Getting the Most From Functional Foods

Researchers are now looking into the bioavailability of nutrients to learn how much of the antioxidants and omega-3 fats we eat are available for our bodies to use.

For now, here are a few tips for you to get the most out of the functional foods you eat:

· Try to buy produce that has been picked at full ripeness and maximum color, an indication of the presence of flavonoids.

· Cook your vegetables in as little water as possible to minimize the amount of nutrients lost in the cooking process.

· Aim to eat fish one to two times each week, and choose from a variety of species, emphasizing cold-water fish.

· Make sure you eat fat-soluble antioxidants like lycopene and vitamins A and E, with a little fat, such as olive oil, to help your body absorb the valuable nutrients.

(Source: http://www.webmd.com/a-to-z-guides/features/antioxidants-and-omega-3-fats-functional-foods-to-boost-health)

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